Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland. Hallamies S, Pelttari LM, Poikonen-Saksela P, Jekunen A, Jukkola-Vuorinen A, Auvinen P, Blomqvist C, Aittomki K, Mattson J, Nevanlinna H. Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review, The potential implications of a PCOS diagnosis on a womans long-term health using data linkage. Secondly, we prioritized variants overlapping with regulatory marks, focusing on genes with modified expression or genes that showed chromatin interaction links with the variants. 2, to provide water storage capacity and to provide an Operations/Maintenance building. Genome-wide significance was set to P < 5 108. The decisions in the first two cases were given in August 2020. In colocalization analyses, all posterior probabilities for a shared causal variant were lower than 0.8. In 2014, Governor Brown signed into law the Sustainable Groundwater Management Act (SGMA), which provides local agencies with authority to manage groundwater basins in a sustainable manner. Backflow Testing - Consolidated Irrigation District No. 19 Additionally, we reran the association analyses including BMI as a covariate, with 2169 cases and 160321 controls from both cohorts. Greville-Heygate SL, Maishman T, Tapper WJ, Cutress RI, Copson E, Dunning AM, Haywood L, Jones LJ, Eccles DM. endobj and T.P. 8:00 am to 5:00 pm. 19 Nevertheless, the identification of these may be difficult in data sets with large genetic variations. Given the register-based approach, we could not assess in more detail the different PCOS phenotypes; however, a previous study indicated that women with PCOS diagnosed by a physician using different diagnostic criteria are genetically similar (Day et al., 2018). Thus, the present study reinforces the links between PCOS, abnormal follicle development and high levels of AMH. There are currently no studies evaluating the pathogenic role of c.1100delC or I157T in Estonians, which underlines the need for further research assessing the impact of these variants in this population. ), Finska Lkaresllskapet (H.L.) Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. An elected, threemember Board of Directors governs the District, which has . Consolidated Irrigation District Fresno Irrigation District Kings County Water District Kings River Conservation District Raisin City Water District . Thus, further functional studies are warranted to characterize the regulatory functions of the uncovered loci (Peltonen et al., 2000; Lim et al., 2014; Martin et al., 2018; Prohaska et al., 2019). For more details see Resolution 2016-6. Biocenter Oulu, University of Oulu, Oulu, Finland. Leveraging Northern European population history: novel low-frequency SELAH-MOXEE IRRIGATION DISTRICT PO Box 166, 113 E. Moxee Avenue Moxee, WA 98936 Phone: (509) 469-0449 Fax: (509) 469-0489 Email: smidistrict@qwestoffice.net Loh PR, Danecek P, Palamara PF, Fuchsberger C, A Reshef Y, K Finucane H, Schoenherr S, Forer L, McCarthy S, Abecasis GR et al. x[oF?F]@Q`ri1E(3pigKpZt8k-"5=N}[o[s=tK{i}]w~Pglu|tQnJ;>2*%N CHEK2 can be considered an important factor in the quality control of cells. Read more. An interaction between BMI and PCOS-associated variants has previously been suggested (Wojciechowski et al., 2012), and interestingly, the c.1100delC variant in CHEK2 has recently been shown to predispose particularly obese carriers to the development of breast cancer (Greville-Heygate et al., 2020). A reduction in the significance of several associations was expected owing to the limited availability of BMI data (60% in FinnGen and 75% in EstBB). Notably, the heritability of PCOS is estimated to be around 70% (Vink et al., 2006; Risal et al., 2019). National Library of Medicine Our study also detected the previously reported associations with PCOS for ERBB4, DENND1A, FSHB and ZBTB16. Biocenter Oulu, University of Oulu, Oulu, Finland. A validation GWAS was performed in the EstBB, including 2812 cases and 89230 controls. The average effect sizes of the novel alleles described in chromosome 22 (OR = 1.693.01) (Table I) were higher than the effects observed for alleles associated with PCOS in the rest of the common variants described (OR = 1.061.40), which could be explained by the often-observed inverse relationship between allele frequency and effect size (Manolio et al., 2009). Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A et al. and Jane and Aatos Erkko Foundation (H.L.). Variant positions were updated to b37 and all variants were changed to be from the TOP strand using GSAMD-24v1-0_20011747_A1-b37.strand.RefAlt.zip files from the https://www.well.ox.ac.uk/~wrayner/strand/ webpage. On March 9, 2022, the Consolidated Irrigation District Board of Directors voted to select its final district map. Martin AR, Karczewski KJ, Kerminen S, Kurki MI, Sarin A, Artomov M, Eriksson JG, Esko T, Genovese G, Havulinna AS et al. In 2014, Governor Brown signed into law the Sustainable Groundwater Management Act (SGMA), which provides local agencies with authority to manage groundwater basins in a sustainable manner. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome, Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity, STAPLER: a simple tool for creating, managing and parallelizing common high-throughput sequencing workflows. Interestingly, even though the association signals found in the EstBB and FinnGen data sets overlap with each other (Fig. We compared our significant loci to all eQTL Catalogue RNA-Seq datasets containing QTLs for gene expression, exon expression, transcript usage and txrevise event usage; eQTL Catalogue microarray datasets containing QTLs for gene expression; and GTEx v7 datasets containing QTLs for gene expression (Kerimov et al., 2021). Under state law, divisions of special districts should: The Board of Directors worked with census data and outside consultants to assess Consolidated Irrigation Districts population and communities of related interests to develop preliminary options for the five divisions of Consolidated Irrigation District by February 2022. pdesatoff@cidwater.com. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Cohort profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. In addition, there was consistency in the direction of effects between our association results and the non-NIH Rotterdam-criteria association results presented in the largest European GWAS meta-analysis to date (Day et al., 2018), which adds robustness to our approach. Rates - Consolidated Irrigation District No. 19 9 0 obj Lee H, Oh JY, Sung YA, Chung H, Kim HL, Kim GS, Cho YS, Kim JT. METAL software was used to perform inverse-variance-weighted meta-analysis for FinnGen and EstBB GWAS results (Willer et al., 2010). 2021 CCR Water Quality Report The meta-analysis also revealed three more variants associating with PCOS, in addition to the three detected in the FinnGen and EstBB GWAS separately (Table I and Supplementary Fig. The horizontal dashed line represents the threshold for genome-wide significance. 19, in addition to its statutory duties, exists primarily to deliver municipal, domestic, industrial, commercial, and irrigation water to the water users of the District in an efficient manner at the lowest possible cost consistent with good management practices. The 150K data freeze was used for the analyses described in this paper. Epidemiological studies show an increased risk for endometrial cancer in women with PCOS. The enrichment of the alleles likely allowed us to detect the associations with PCOS in the Finnish and Estonian populations, whereas in populations with lower minor allele frequencies, much larger study populations would need to be used. Functional characterization of this locus revealed a frameshift variant, c.1100delC (rs555607708, P = 1.68109, OR = 13.46 [5.6831.89]) in CHEK2, with a high LD (r2 = 0.95) with the lead variant. 2014 CCR Water QualityReport <> CID No. Repair And Replacement CID's infrastructure dates back to the late 1800's and therefore requires investment in repairing and replacing these vital resources. Read more. CHEK2 rs555607708 (c.1100delC), the likely association-driving variant in FinnGen, is a Finnish-enriched variant with a 3.7-fold enrichment compared to non-Finnish, non-Estonian Europeans and with an enrichment of 1.7 compared to Estonians (Mars et al., 2020). Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. An integrated map of genetic variation from 1,092 human genomes, Hyperandrogenic origins of polycystic ovary syndromeimplications for pathophysiology and therapy, Introduction: determinants of polycystic ovary syndrome, Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. In this study, we found two independent novel associations for PCOS on 22q11.2. Correspondence address. Located in southern Fresno County, District's exterior boundaries enclose approximately 163,000 acres of land, of which about 145,000 acres are irrigated agricultural land. Active Irrigation Organizations - Idaho Department of Water Resources administrated the project and provided feedback. J.S.T., N.P.-G., T.L., E.S. Interestingly, CHEK2 also plays a crucial role in foetal oocyte attrition, a phenomenon through which 80% of the initial ovarian oocyte reserve is lost during foetal development in mammals (Tharp et al., 2020). The EstBB lead variant had a P-value of 1.8105 in FinnGen (Table I). Watanabe K, Taskesen E, van Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. ), Finska Lkaresllskapet (H.L.) However, this does not apply to other gynaecological cancers like ovarian, cervical or breast cancer (Barry et al., 2014; Gottschau et al., 2015; Hart and Doherty, 2015; Harris and Terry, 2016; Ding et al., 2018). Serum anti-Mullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. Ward LD, Parker MM, Deaton AM, Tu H, Flynn-Carroll A, Hinkle G, Nioi P. Rare coding variants in five DNA damage repair genes associate with timing of natural menopause. RCW 87.03.535: Consolidation of irrigation districtsProceedings for Center for Life Course Health Research, Faculty of Medicine, Aapistie 5A, PO Box 5000, 90014 University of Oulu, Oulu, Finland. Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; genome-wide association study, rare variants, polycystic ovary syndrome, checkpoint kinase 2, myosin X, {"type":"entrez-protein","attrs":{"text":"VRK43431","term_id":"1645284850","term_text":"VRK43431"}}. Forest plot of effect estimates for the seven lead variants associated with PCOS. A final plan was submitted to the Board of Directors for a vote of approval at their meeting on March 9, 2022. and transmitted securely. Prohaska A, Racimo F, Schork AJ, Sikora M, Stern AJ, Ilardo M, Allentoft ME, Folkersen L, Buil A, Moreno-Mayar JV et al. The general service areas are from Flora Road east to the Idaho border, excluding Liberty Lake and Newman Lake. government site. Nevertheless, three recent studies utilizing a Mendelian randomization approach have suggested a modest but significant causal effect between PCOS and breast cancer (Wu et al., 2020; Wen et al., 2021; Zhu et al., 2021). Piltonen T, Morin-Papunen L, Koivunen R, Perheentupa A, Ruokonen A, Tapanainen JS. Day F, Karaderi T, Jones MR, Meun C, He C, Drong A, Kraft P, Lin N, Huang H, Broer L et al. Consolidated Irrigation District No. PDF Publication Of In order to synchronize the build of the datasets, we lifted the FinnGen GWAS summary statistics over to hg37 build using UCSC liftOver (Kent et al., 2002) before running the meta-analyses. The site is secure. Helsinki-Uusimaa Region - Helsinki-Uusimaa Regional Council the contents by NLM or the National Institutes of Health. Human disease variation in the light of population genomics, R: A Language and Environment for Statistical Computing. The map met all redistricting criteria and made the least number of changes to the 2010 approved map. Section 3 Objectives of the District [A] Consolidated Irrigation District No. As a result, we unravelled two rare, population-enriched variants located in the checkpoint kinase 2 (CHEK2) gene and described one novel variant in the intron of the myosin X (MYO10) gene. In both cases, the lead single nucleotide polymorphisms had tightly linked variants, a frameshift (c.1100delC) and a missense (I157T), in the CHEK2 gene. Reference-based phasing using the Haplotype Reference Consortium panel. Moreover, we observed consistency in the direction of effects between the three datasets analyzed (discovery, validation and joint meta-analysis) (Fig. Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome. The backflow testing process checks your plumbing to ensure dirty water does not infiltrate the drinking water supply. Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland. Polycystic ovary syndrome (PCOS) is a common, multifaceted endocrine disorder. Analyses in the EstBB were carried out under ethical approval 1.1-12/624 from the Estonian Committee on Bioethics, and Human Research and data release N05 from the EstBB. Contact Us - Consolidation Irrigation District The authors declare no conflicts of interest. 2069, Consolidated Irrigation District, Corcoran Irrigation District, Empire West Side Irrigation District, Fresno Irrigation District, James Irrigation District, Kings County Water District, Kings River Water District, Laguna Irrigation District, Lakeside . Women with PCOS also have an increased risk for endometrial cancer; however, the majority of studies do not indicate a higher susceptibility to other types of cancer (Dumesic and Lobo, 2013; Barry et al., 2014; Gottschau et al., 2015; Ding et al., 2018). stream The third new association peak in the meta-analysis (rs9312937, P = 1.7 108, OR = 1.16 [1.101.22], AF = 0.44) was a common variant in an intronic region of chromosome 5, located 100 kb from the TSS of the MYO10 gene, which to our knowledge has not previously been associated with PCOS. Blank form to provide to your certified tester - Backflow Prevention Assembly Test Report Email a photo of the completed Backflow Report to cidoffice@comcast.net Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. 2020 CCR Water Quality Report 2B). Please refrain from calling to see if weve received your report were entering them as quickly as possible and will send out a second notice after the July 30 deadline calling for any missing reports. endobj CHEK2 is a mediator of DNA damage signalling in response to double-stranded DNA breaks. 2A). The main strength of this study was the use of the two large, comprehensive genetic data sets, FinnGen and the EstBB, which have been extensively linked to national registers, such as the CRCH in Finland and the Estonian Health Insurance Fund registries in Estonia, as well as with other relevant databases (Leitsalu et al., 2015). We proceeded to test associations using a stepwise analysis, where markers were added to the model until no independent signals were identified. A discovery GWAS with 797 PCOS cases and 140558 controls in the FinnGen study uncovered two loci close to ERBB4 and DENND1A that have previously been shown to be associated with PCOS. Prop 218 - Consolidation Irrigation District Spokane Valley, WA 99212 The documents on this page will help you through the process, please start with General Notes for Water System Construction. Gene-based analysis was also performed in this platform using MAGMA (de Leeuw et al., 2015). Enter your address in the top right corner and the tool will tell you your CID division. We identified PCOS cases from national registers by ICD codes (ICD-10 E28.2, ICD-9 256.4, or ICD-8 256.90), and all remaining women were considered controls. 8600 Rockville Pike 2017 CCR Water Quality Report This study is reported according to the Strengthening the Reporting of Genetic Association Studies (STREGA) guideline. Individuals were excluded from the analysis if their call rate was <95% or if their sex defined by heterozygosity of X chromosomes did not match their sex in the phenotype data. Vink JM, Sadrzadeh S, Lambalk CB, Boomsma DI. The Market Court imposed a total penalty payment of EUR 50.000 on HUS regarding the direct procurement of waste disposal bags and tissue paper products.14 The next two decisions on the direct The District. Also, BMI data were not available for all (63% for FinnGen, 76% for EstBB), and the biobank setting limited the accessibility of PCOS phenotypes and laboratory values. Local Water Utilities United for Safe Drinking Water The Spokane Aquifer was designated as a "sole source" in 1978 by the Environmental Protection Agency. The funders had no role in study design, data collection and analysis, publishing or preparation of the manuscript. endobj The criteria result in a prevalence as high as 18% for PCOS among fertile-aged women and produce several phenotypes (March et al., 2010; Skiba et al., 2018). Red Cross - Helsinki-Uusimaa | Helsinki - Facebook Consolidated Irrigation District Company Profile | Selma, CA | Competitors, Financials & Contacts - Dun & Bradstreet Consolidated Irrigation District No. 19 - Spokane Aquifer Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland. Hassayampa Water Coop 26. A specific association between menopause-delaying alleles and PCOS has also been previously demonstrated (Day et al., 2015). The MYO10 gene codes for an atypical myosin, which is involved in filopodia formation, phagocytosis and cargo transport in cells (Sousa and Cheney, 2005). Although only covering three percent (9,440 km 2) of our national land area, our Region is home to around 1.7 million inhabitants, which is about a third of the country's total population. Both populations are genetically well-characterized (Salmela et al., 2008). A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation. Meta-analysis results of the genome-wide association studies from Estonian Biobank (EstBB) and FinnGen are shown in italics. info@spokaneaquifer.org, Local Water Utilities United for Safe Drinking Water, 120 N. Greenacres RoadGreenacres, WA 99016, Backflow Protection & Cross Connection Control, eBook: Household Waste & Water Conservation, Middle School Water Conservation Trailhead, Click here for answers to frequently asked questions . Department of Clinical Genetics, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland. _Z}>>J?jZ||ti]ReSr\On|W/T2CL|04KtQ*o||qZfcu,G_bu# 6(D^aYy>T']@PBFE4 Home - Consolidation Irrigation District We identified three novel genome-wide significant associations with PCOS, with two putative independent causal variants in the checkpoint kinase 2 (CHEK2) gene and a third in myosin X (MYO10). Fredonia Consolidated Irrigation and Mfg. 2015 CCR Water Quality Report The Biobank access decisions for FinnGen samples and data utilized in the FinnGen data freeze R6 include: THL Biobank BB2017_55, BB2017_111, BB2018_19, BB_2018_34, BB_2018_67, BB2018_71, BB2019_7, BB2019_8, BB2019_26, BB2020_1, Finnish Red Cross Blood Service Biobank 7.12.2017, Helsinki Biobank HUS/359/2017, Auria Biobank AB17-5154, Biobank Borealis of Northern Finland_2017_1013, Biobank of Eastern Finland 1186/2018, Finnish Clinical Biobank Tampere MH0004, Central Finland Biobank 1-2017 and Terveystalo Biobank STB 2018001. Each parcel is assessed a base rate for a domestic service line and an irrigation rate depending on the size of the property. Para aprender ms sobre el funcionamiento de este proceso, por favor contctenos: (559) 896-1660. Office hours: The findings emphasize the benefits of utilizing isolated populations in genetic studies of complex diseases and advance the understanding of genetic factors underlying PCOS. 3 0 obj This would be in line with women with PCOS, as they also present with an increased ovarian reserve, higher AMH levels, even at later reproductive years, and delayed menopause (Piltonen et al., 2005; de Ziegler et al., 2018; Minooee et al., 2018; Forslund et al., 2019; Ward et al., 2021). Annual Report on Competition Policy Developments in Finland - OECD Labor Day Veterans Day Thanksgiving Day and the Friday after CID is responsible for local, state and federal regulatory compliance and reporting. Nelis M, Esko T, Mgi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskkov T, Balak I, Peltonen L et al. However, the tight LD spans an area of approximately 2 Mb surrounding the lead variant with many variants in high LD (Fig. Mitt M, Kals M, Prn K, Gabriel SB, Lander ES, Palotie A, Ripatti S, Morris AP, Metspalu A, Esko T et al. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome. FUMA uses GWAS summary statistics and performs extensive functional annotation and candidate gene mapping using positional, expression quantitative trait loci (eQTL) and chromatin interaction mapping in all genome-wide significant loci. Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J et al. These events have led to an enrichment of many low-frequency variants almost absent in most European populations (1000 Genomes Project Consortium et al., 2012; Nelis et al., 2009; Locke et al., 2019). Deletion of Chk2 in mice leads to a maximized ovarian reserve at postnatal day 2 (Tharp et al., 2020) and reduced follicle atresia, a higher number of ovulated metaphase II oocytes, and higher AMH levels at 13.5 months (Ruth et al., 2021). Careers, Unable to load your collection due to an error. The population-specific imputation reference of 2297 whole-genome sequencing samples was used (Mitt et al., 2017). Furthermore, gene functions were examined in GenBank and UniProt portals. Riikka K Arffman, Delinquency fees will be applied on unpaid balances past the due date per Resolution 2022-6. We issued an unmodified opinion on the fair presentation of the . Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes. J.S.T., R.K.A. Finnish Institute for Health and Welfare, Helsinki, Finland. <>>> CID provides irrigation water deliveries, water right protection, groundwater management and rechar Consolidated Irrigation District | Selma CA Consolidated Irrigation District No. Bill Stretch Manager Fresno Irrigation District 2907 S. Maple Avenue Fresno, CA 93725 . Consolidated Irrigation District No. 14 - Washington Lim SS, Kakoly NS, Tan JWJ, Fitzgerald G, Bahri Khomami M, Joham AE, Cooray SD, Misso ML, Norman RJ, Harrison CL et al. 19, as of and for the years ended December 31, 2021, 2020 and 2019, and the related notes to the financial statements, which collectively comprise the District's financial statements, and have issued our report thereon dated October 19, 2022. When the FinnGen and EstBB results were conditioned for the c.1100delC and I157T variants and the results were meta-analyzed, there were no additional genome-wide significant signals in the CHEK2 locus. Consolidation Irrigation District Copyright 2023 - All Rights Reserved. 19, located in Greenacres in the Spokane Valley, began operations in 1966. Leveraging polygenic functional enrichment to improve GWAS power. Blank form to provide to your certified tester , Email a photo of the completed Backflow Report to. PDF Redistricting Preliminary Options Overview Home; Your Account. Sample genotyping in FinnGen was performed using Illumina and Affymetrix arrays (Illumina Inc., San Diego, and Thermo Fisher Scientific, Santa Clara, CA, USA). Consolidated Irrigation District No. ), 297338 (J.K.), 307247 (J.K.), 344695 (H.L. The register-based approach is also a limiting factor, as the health register-based prevalence of PCOS is very low in our study populations (0.57% for FinnGen and 3.15% for the EstBB), plausibly reflecting underdiagnosis of the syndrome. Sprinkler systems are required to have a backflow prevention device. Regional plots were produced with R-package LocusZooms (https://github.com/Geeketics/LocusZooms/). Muranen TA, Blomqvist C, Drk T, Jakubowska A, Heikkil P, Fagerholm R, Greco D, Aittomki K, Bojesen SE, Shah M et al. 2255 Chandler Ave | PO Box 209 Selma | Phone: 559-896-1660 | Fax: 559-896-8488. 7:00 pm at the District Office. The GWAS meta-analysis summary statistics that support the findings of this study are available for download from the GWAS Catalog at ebi.ac.uk/gwas/ with accession ID numbers GCST90044902 and GCST90044903. Sprinkler systems are required to have a backflow prevention device. We further assessed the robustness of our PCOS definition by comparing the effects sizes between the lead variants in the replicated loci presented in the non-NIH Rotterdam criteria (Day et al., 2018) to our association results. Plaintiff Consolidated Irrigation District (District) is an independent special district formed under the California Water Code. Minooee S, Ramezani Tehrani F, Rahmati M, Mansournia MA, Azizi F. Prediction of age at menopause in women with polycystic ovary syndrome. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. 2022 Consolidated Irrigation District No. endobj de Leeuw CA, Mooij JM, Heskes T, Posthuma D. MAGMA: generalized gene-set analysis of GWAS data. Sole Source means the aquifer is our only affordable source of drinking water in a bi-state region serving more than 600,000 people daily. Independent FinnGen and Estonian Biobank (EstBB) GWAS associations overlapping the checkpoint kinase 2 (CHEK2) gene are plotted on a single LocusZooms figure. Each additional unit will be allowed 400 cubic feet of usage and charged an additional $5.00 base rate per month. In the discovery dataset, an additional association analysis including BMI as a covariate was conducted with a total of 482 PCOS cases (60.5% of the original PCOS sample) and 91631 controls from FinnGen (65.2% of the original control sample).
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